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Toxicity studies: Chronic
Chronic (26-52 wk)
Toxicity studies: Subchronic
Record Type:Study
Validation:Non-GLP,GLP
Models:Mouse,老鼠,Rabbit,Canine,Mini-pig,NHP
Disease:Asthma & Allergy,Autoimmune & Inflammatory,Cardiology,CNS,Dermatology,Gastroenterology,General Medicine,Hematology,Infectious Disease,Metabolic Endocrine,Musculoskeletal,NASH,肾脏学,Oncology,Ophthalmology,Pediatrics,Pulmonary Respiratory,Rare Disease,Renal Hepatic,Reproductive Health,Rheumatology,Urology
Subchronic Toxicity Studies are used to determine crucial parameters forchronic toxicity studies, which include, but are not limited to the following:
- Establish adverse effects, not detected in short-term studies
- Identify the observed effect of dose levels and NOAEL (no-observed-adverse-effect-level)
- Provide data for dose selection for chronic toxicity
- Identify the target organ/site of action
- Provide data extrapolation for regulatory agencies
- Forecast a risk assessment
Subchronic Toxicology Studies are typically ordered for 28-day or 90-day timeframes; but other options are possible.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.