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ADME研究和米etabolite identification
Animal, Metabolite Identification, Environmental, Radiolabeled, ADME
Metabolite profiles (species comparison)
Record Type:Study
Models:Mouse,老鼠,Guinea Pig,Hamster,Rabbit,Canine,Feline,Mini-pig,Bovine,Marmoset,Human
Cross-species metabolite profiling and identification (MetID) studies help to understand the biotransformation of the test article. This information can be applied to understand the potential for enzymatic-based mechanisms of clearance across species. These data can be used help determine the appropriate species for nonclinical safety studies to ensure compliance with the ICH M3(R2)/MIST guidelines.
The FDA recommends the use of in vitro interspecies metabolic comparisons at an early stage in the drug development process. Knowledge about the metabolism of a compound is also important from a drug discovery perspective. In vivo metabolism study results will either confirm the results obtained from the in vitro studies or reveal quantitative and/or qualitative differences in metabolism across species.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.