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OECD 402 / OCSPP 870.1200：急性皮肤毒性
急性
毒性研究：急性（单剂量）
录制类型：学习
Validation:GLP,非GLP.
Models:Mouse,老鼠,兔子,犬,NHP.
Disease:哮喘和过敏,自身免疫和炎症,心脏病学,CNS.,Dermatology,Gastroenterology,一般用药,血液学,Infectious Disease,Metabolic Endocrine,肌肉骨骼,纳什,肾脏学,Oncology,眼科,Pediatrics,肺呼吸道,罕见的疾病,Renal Hepatic,生殖健康,Rheumatology,泌尿外科
急性toxicity is produced by an active ingredient when administered in one or more doses during a maximum period of 24 hours. The test uses two mammalian species, including one nonrodent.
目的是鉴定剂量导致没有不良影响和剂量导致主要，危及生命的毒性。
从单剂量研究获得的信息可用于选择剂量，用于重复研究，提供毒性靶器官的初步鉴定。
急性toxicity studies may also aid in the selection of starting doses for Phase I human studies and provide information relevant to acute overdosing in humans.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。