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滥用责任评估：毒品歧视
Abuse Liability
滥用责任评估：自我管理
A self-administration study assesses the potential of a drug to maintain lever-pressing behavior due to its positive reinforcing effects.
If the test drug produces a high level of self-administration compared to vehicle, there is a good probability that the drug will produce rewarding properties in humans that are supportive of drug abuse.
The intravenous route of administration should be used to optimize the temporal association between active lever-pressing and immediate drug effects.
该研究类型是为了评估测试代理的奖励和加强潜力，并形成CNS活性药物所需的监管所需滥用责任评估的一部分。
必须使用GLP进行滥用相关的非卷轴研究，因为这些研究是支持人类使用药物的非临床实验室研究。
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。