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ADA positive control testing services
Monoclonal, Polyclonal
熊猫（PEG和酸）测定
录制类型：Technique
生物治疗剂的给药具有诱导不希望的免疫原性的潜力，导致可能导致过敏反应，改变药代动力学（PK）和降低疗效的抗药物抗体（ADA）。具有长半衰期或高剂量或靶标的生物治疗剂可能会干扰检测ADA，导致假阴性（来自药物）或假阳性结果（来自目标）。为了克服这些限制，已经开发出沉淀和酸解离测定，也称为PEG和酸（熊猫）测定。该方法旨在在样品中的药物存在下检测ADA（免费ADA和药物结合ADA）。
First, the samples are incubated with excess drug to saturate ADA to form drug-ADA complexes. The complexes are then precipitated using polyethylene glycol (PEG) and then subjected to an acid solution for dissociation. Free ADA (and free drug) are captured on plates and incubated with the sulfo-tagged drug for the specific detection of the ADA.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。