吸入product testing: Particle size distribution

Pharmaceutical inhalation products, including metered-dose inhalers (MDIs) and dry powder inhalers (DPIs), are devices that deliver a specific quantity of drug to the lungs.

The particle size distribution and shape of the delivered dose is critical because these determine the inhaled dose (which can be absorbed and exert a therapeutic effect) and how much is deposited in the lungs.

最佳的空气动力学粒度分布通常被认为是1-5μm的范围。使用级联撞击仪的分析用于吸入器和雾化器的空气动力学粒子。

通过使用级联撞击器从吸入装置收集几个粒度分数，然后使用测定（例如HPLC）分析它们的含量来进行该方法。

确定粒度分布的其他常见技术是动态图像分析（直径），静态激光散射（SLS，也称为激光衍射），动态光散射（DLS）和筛分分析。