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OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
遗传，急性, In Vitro Alternate
OECD 489: Alkaline comet assay (in vivo mammalian)
在体内碱性彗星（单细胞凝胶电泳）测定中用于鉴定通过检测从动物的多个组织中分离的细胞或细胞核中的DNA链或核，通常暴露于潜在的遗传毒性材料的DNA链或核。
The nuclear DNA undergoes electrophoresis under alkaline conditions (>pH 13) and results in structures resembling comets which can be observed by fluorescent microscopy. The amount of DNA breakage is based on migration of the DNA fragments.
The assay can detect single and double stranded breaks which may be repaired, resulting in no persistent effect, may be lethal to the cell, or may be fixed into a mutation resulting in a permanent viable change. They may also lead to chromosomal damage which is also associated with many human diseases including cancer.
Related Capabilities
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经合组织405 / OCSPP 870.2400: Acute eye irritation/corrosion
遗传，急性 -
OECD 476：细胞基因突变试验（HPRT基因，体外哺乳动物）
毒理学，遗传学 -
OECD 489: Alkaline comet assay (in vivo mammalian)
毒理学，遗传学 -
OECD 473: Chromosome aberration test (in vitro mammalian)
毒理学，遗传学 -
微核机械后续行动
毒理学，遗传学 -
经合组织475：骨髓染色体畸变试验（哺乳动物）
毒理学，遗传学 -
OECD 474: Erythrocyte micronucleus test (in vivo mammalian)
毒理学，遗传学 -
OECD 490：使用胸苷激酶基因（MLA TK，体外哺乳动物）的细胞基因突变试验
毒理学，遗传学 -
OECD 471：细菌反向突变试验（AME）
毒理学，遗传学 -
经合组织488：转基因啮齿动物体细胞和生殖细胞基因突变测定（Muta™小鼠）
毒理学，遗传学 -
OECD 404: Acute skin irritation
毒理学，遗传学, Acute -
OECD 487: Cell micronucleus test (in vitro mammalian)
毒理学，遗传学 -
Toxtracker®Mastay.
毒理学，遗传学 -
Erythrocyte pig-a gene mutation assay (rodent)
毒理学，遗传学 -
Toxicity studies: Acute
遗传，急性 -
局部淋巴结测定（LLNA）
遗传，专业，急性 -
Eye irritation
遗传，体外交替，急性 -
Skin irritation & corrosion studies
遗传，急性
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。