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OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
遗传, Acute, In Vitro Alternate
OECD 487: Cell micronucleus test (in vitro mammalian)
的体外Micronucleus Test investigates genotoxic damage by detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may be the result of aneugenic (whole chromosome) or clastogenic (chromosome breakage) damage; therefore, this test provides a comprehensive basis for investigating chromosome damaging potential in vitro. Further analysis can provide distinction between aneugenic and clastogenic events by using anti-kinetochore antibodies or fluorescence in-situ hybridization (FISH) with pan-centromeric DNA probes.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。