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经合组织505：牲畜中的残留物
Bioanalysis, Toxicology, Animal, Metabolite Identification
OECD 440: Uterotrophic assay
录制类型：测定
Disease:Metabolic Endocrine
The OECD 440: Uterotrophic Assay in rodents assesses the effects of a chemical on female rodents at two physiological stages in which the hypothalamic-pituitary-ovarian axis is not functional and oestrogen sensitivity is heightened. In both prepubescent females and mature females post-ovariectomy, a substance is adminstered orally or subcutaneously for three days before undergoing necropsy to assess increase in uterine weight or uterotrophic response.
Related Capabilities
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。