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OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
Genetic, Acute, In Vitro Alternate
经合组织438：孤立的鸡眼试验（具有任选的组织病理学）
录制类型：学习
经合组织438：体外进行分离的鸡眼测试，并确定物质是否是眼睛刺激物。通过测量角膜肿胀来定量评估该物质的效果，并通过研究基于荧光素潴留的缺点和对眼睛的损伤来定性进行定性。这些评估在一起，导致产生一种刺激性分类，这预测物质在体内的损害。然后可以通过眼睛刺激剂是否会造成严重的眼睛损伤来分类物质。
角膜的组织病理学是一种可选的额外，可以改善测试剂在体内对试剂的影响的预测性。
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。