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OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
Genetic, Acute, In Vitro Alternate
OECD 437: BCOP (bovine corneal opacity permeability)
经合组织437：牛角膜不透明度和渗透率（BCOP）测定是1992年最初描述的体外方法，以预测使用活牛角膜组织的测试化学品的体内眼睛刺激潜力。通过使用可见光分光光度计的粘膜镜和渗透率，通过角膜不透明度的变化定量评估由化学物质暴露引起的损伤类型。不透明度的变化是通过测量通过角膜透过的光量来确定的，并且通过穿过角膜穿透的荧光素染料的量来测量渗透性的变化。
两种测量用于计算体外刺激性评分（IVIS）以分配体外刺激性危害分类类别，用于预测测试化学品的体内眼刺激潜力。
Information about corneal opacity and permeability give further insights into the mechanism of damage, e.g. opacity damage can be caused by protein denaturation or the induction of stromal swelling.
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