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OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
Genetic, Acute, In Vitro Alternate
OECD 435: In vitro skin corrosion (Corrositex®)
Skin corrosion refers to the production of irreversible tissue damage in the skin following the application of a test material. The potential for chemical induced skin corrosion is an important consideration in establishing procedures for safe handling, packing and transport of chemicals.
The commercially available Corrositex® model has undergone formal validation and has been accepted by regulatory authorities for skin corrosion testing. The in vitro assay system is composed of two components, a synthetic macromolecular barrier and a chemical detection system (CDS).
The more corrosive a test substance, the shorter time it takes to penetrate (break through) the biobarrier and effect a color change. Noncorrosive substances do not disrupt the barrier, or disrupt the barrier too slowly to be identified as corrosive.
Related Capabilities
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OECD 432: In vitro phototoxicity (Balb/c 3T3)
Toxicology, In Vitro Alternate -
OECD 439: In vitro skin irritation (EpiSkin™ / EpiDerm™)
Toxicology, In Vitro Alternate -
OECD 493: Human recombinant estrogen receptor (hrER)
In Vitro Alternate -
OECD 442E: Human cell line activation test (h-CLAT)
Toxicology, In Vitro Alternate -
OECD 455: Estrogen receptor transcriptional activation (ERTA)
Toxicology, Endocrine, In Vitro Alternate -
OECD 435: In vitro skin corrosion (Corrositex®)
Toxicology, In Vitro Alternate -
OECD 456: H295R Steroidogenesis assay
Toxicology, Endocrine, In Vitro Alternate -
OECD 437: BCOP (bovine corneal opacity permeability)
Toxicology, In Vitro Alternate -
OECD 438: Isolated chicken eye test (with optional histopathology)
Toxicology, In Vitro Alternate -
Cytoxicity assays for ISO/ICCVAM/HC: Balb/c C3T3; L929; MRC5
Toxicology, In Vitro Alternate -
OECD 492: Ocular irritation and EpiOcular™ (in vitro)
Toxicology, In Vitro Alternate -
OECD 442D: KeratinoSens™ assay
Toxicology, In Vitro Alternate -
OECD 431: In vitro skin corrosion (3D model)
Toxicology, In Vitro Alternate -
Eye irritation
Genetic, In Vitro Alternate, Acute
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.