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OECD 421: Reproduction/developmental toxicity screening test
投掷
OECD 422：联合重复剂量毒性研究（w/筛选）
The objectives of the Combined Repeated Dose Toxicity Study with the reproduction/developmental toxicity screening test are to examine chemical exposure on male and female reproductive performance, in addition to the standard requirements for Repeat Dose General Toxicity studies of 4-week duration (OECD 407).
The study design is a combination of the OECD 421 test guideline and the OECD 407 test guideline and therefore adds additional endpoints including clinical pathology, full histopathology and neurobehavioral assessments.
Related Capabilities
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解更多关于我们的承诺，以取代，重用和完善非临床研究模型。