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OECD 410/OCSPP 870.3200：皮肤毒性研究（重复剂量，21/28天）
亚慢性（0-26周）
OECD 407/OCSPP 870.3050: Oral toxicity study (repeated dose, 28-Day)
OECD 407：重复剂量28天口服毒性研究用于确定口服摄入化学品的毒性。建议在大鼠身上进行试验，但也可使用其他啮齿类动物，试验包括将动物分为亚组，并通过灌胃或通过食物/水，在28天内给各组注射不同的固定剂量的试验物质。在此期间，进行临床和功能评估，以确定化学品的毒性和健康危害。
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解更多关于我们的承诺，以取代，重用和完善非临床研究模型。