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Histopathological assessments: Ocular
Pathology, Toxicology, Anatomic Pathology, Ocular tox
Osmotic & iPrecio® Pump (ocular implants)
Osmotic and iPrecio® implants can be used for ocular studies.
These implantable pumps deliver a therapeutic agent in vivo while the model is undisturbed, recording parameters. Small, concentrated doses of the test therapy (within the nanoliter to microliter range) are instilled by the pump directly into the intraocular space, while avoiding animal distress of repeat intraocular injections.
iPRECIO® micro pumps are programmable and refillable; a micro-motor drives a peristaltic-like movement to release the therapy. Osmotic pumps are single-use and rely on osmotic displacement to diffuse the therapy.
These reservoir-based systems may be implanted within a subcutaneous pocket in the lateral fornix or subconjunctivally, depending on the study. Often one eye can hold the therapy, allowing the other to be a control.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.