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透射电子显微镜(TEM) services & reporting
Pathology, Specialty Pathology
Immunohistochemistry (IHC)
Record Type:Technique
Validation:GLP,Non-GLP
Models:Mouse,Rat,Rabbit,Canine,Mini-pig,NHP,Human
Disease:Oncology
Immunohistochemistry (IHC) is a technique that utilizes antibodies that specifically recognize and bind different antigens in cells or tissue samples. The technique uses antibodies that are either conjugated to enzymes or a fluorescent dye to allow visualization of the distribution and localization of specific cellular components under a microscope.
The table below lists some examples of the cells which can be determined through CD markers via IHC across our facilities worldwide.
Immune Cells (CD45*) |
Species |
||||||
|---|---|---|---|---|---|---|---|
NHP |
Mouse |
Rat |
Porcine |
Canine |
Human |
||
Lymphoid |
T lymphocytes |
CD3, CD4, CD8, CD16, CD278 |
CD3, CD4, CD8 |
CD3, CD8 |
CD3, CD8 |
CD3, CD4, CD8 |
CD3, CD4, CD8 |
B lymphocytes |
CD19, CD20, CD21, CD79a, CD138 |
CD19, CD20, CD79a, CD45R |
CD79a |
CD79a |
CD20 |
CD20 |
|
NK cells |
CD8, CD16 |
CD8 |
CD8 |
CD8 |
CD8 |
CD8 |
|
Myeloid (Macrophages, Dendritic cells, Mast cells, Granulocytes) |
CD68, CD4, CD16, CD123, CD205, CD207, CD209, CD303 |
CD68, F4/80, CD4, CD117 |
CD68 |
CD4 |
CD68, CD66b, CD4 |
||
Read the blog post on the relationship between immunophenotyping & immunohistochemistry. [LINK COMING]
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.