Histopathological assessments: Ocular

Record Type:Study

疾病:Ophthalmology

作为组织病理学过程的一部分,将与眼睛(眼睑,泪腺,淋巴细胞,排出淋巴结等)相关联的组织列表,作为组织病理学过程的一部分。组织被鉴定为“左”或“右”,并在所有过程中分别维持,以将可能的微观结果与剂量给药相关。

Alternatively, various sub-anatomic structures may be isolated from the eye via fresh or frozen tissue techniques for use in bioanalytical or other analyses. Modified Davidson's fixative is the fixative of choice for histology; however, a variety of fixation methods may be recommended based on species, dose design, and the purpose of the study.

对于包括大多数眼部研究的大型动物物种,在物种特异性和剂量特异性关键标志性地标染色的苏木精和曙红(H&E)制备至少三种载玻片。必要时,技术人员与眼部聚焦的解剖病理学家合作,开发学习特定的修剪飞机,以获得眼睛的最佳组织病理学评估。

Additional slides may be taken from paraffin blocks via serial sectioning or step sectioning to allow for additional H&E staining, immunohistochemistry or, to better demonstrate specific ocular components, other special staining protocols.

Industry Market

Pharma