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眼睛刺激
眼睛刺激is defined as the production of changes in the eye following the application of a test substance to the anterior surface of the eye. These changes are fully reversible within 21 days of application (UNECE, Part 3.3, 2015). It is a key toxicological endpoint required to achieve fundamental product safety standards and to guide therapy development. There are various eye irritation test models; one example is in vitro bovine corneal opacity and permeability (BCOP) assays. These can be used to screen substances early on in development or during GLP toxicity testing.
关于我们非临床的动物研究模式：我们为我们的研究动物提供最大的关怀，积极追求动物福利的进步。除了确保最高的科学，道德和监管标准，选择适当的动物研究模型对于开发保护和拯救生命的安全有效的治疗，设备和产品至关重要。正如我们有道德委员会对人类试验的监督一样，我们有伦理委员会监督我们全球动物护理和使用计划的各个方面。我们所有的核心，非临床设施都被Aaalac认可。Learn more about our commitment to replacing, reusing and refining nonclinical research models.