Abuse liability assessments: Drug discrimination

Record Type:评估

验证:GLP.

楷模:

药物歧视研究评估药物诱导与已知滥用药物产生的中断刺激(感觉)的刺激的潜力。进行这些研究以评估具有已知滥用药物的新型测试剂的心理和身体感知。

Drugs within the same pharmacological class share comparable interoceptive stimuli and are known to substitute for each other in the drug discrimination test.Thus, if the test drug has a novel mechanism of action, an alternative approach may be preferable for identifying an appropriate training drug. The test forms a part of the regulatory required abuse liability assessment for central nervous system active drugs.