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OECD 453 / OCSPP 870.4300：组合慢性毒性/致癌性研究
致癌性，慢性（26-52周）
Toxicity studies: Chronic
录制类型：学习
Validation:GLP
Models:Mouse,老鼠,犬,迷你猪,NHP.
Disease:哮喘和过敏,自身免疫和炎症,心脏病学,CNS.,Dermatology,Gastroenterology,一般用药,血液学,Infectious Disease,Metabolic Endocrine,肌肉骨骼,纳什,肾脏学,Oncology,眼科,Pediatrics,肺呼吸道,罕见的疾病,Renal Hepatic,生殖健康,Rheumatology,泌尿外科
慢性毒性研究提供了有关可能在相当一部分的测试物种寿命中反复暴露可能产生的健康危害的信息。
Studies provide data about toxic effects of a substance, indicate target organs and the possibility of accumulation. They can also provide estimates of no-observed-adverse effect levels to help establish safety criteria for human exposure.
Test duration ranges from 26 to 52 weeks, depending on test species. The majority of chronic toxicity studies are carried out in rodent species, but NHP are also used.
用于慢性毒性研究中使用的三种主要施用途径是口服，皮肤和吸入的。该路线的选择取决于测试化学品的物理和化学特征和人类暴露的主要途径。
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。