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In Silico
在Silico评估中使用先进的计算模型来迅速预测化学品的潜在毒性，而无需动物检测。在Silico技术中，随着计算能力，科学知识和化学品的信息，正在改善。通过与Covance合作，您可以访问Silico的专业知识预测对回答有关您的化学品的安全问题并向设计进行任何体外研究计划的设计至关重要。
Robust in silico predictions meeting regulatory endpoints efficiently
- A dedicated team of computational biologists, statisticians, chemists, toxicologists and regulatory experts ensure robust in silico toxicology predictions to support weight of evidence arguments supporting your chemical
- 使用基于专业规则和基于统计的基于统计的方法的广泛的计算建模工具套件。
- 在Silico预测中，集成到更广泛的测试方法中，以优化您的学习花费，并帮助您对监管机构提出令人信服的论据
您的需求
你怎么predict the toxicity of your chemical without testing if there is little or no experimental data available?
Avoiding both in vitro and in vivo testing may be necessary if budgets and regulatory timelines are tight. In silico predictions, based on computer modelling, combined with read-across approaches can build a weight of evidence argument for regulators. However, running the models and interpreting the predictions as part of a WOE approach requires high levels of experience, skill and regulatory insight.
How do you optimize and target your spend on toxicity testing?
To optimize your budget for toxicology testing, you must take a strategic approach to study planning. In silico approaches can help you establish the optimum focus for your study program and the tests that will best deliver reliable outcomes in a cost and time efficient manner.
Our Capabilities
Covance结合了计算生物学，统计学，化学和毒理学的专业知识，以促进硅毒理学预测对您的化学物质的引人注目
Meaningful in silico predictions can only be made by people who understand the chemistry, toxicology and the statistical basis behind QSAR models. By working with Covance, you will have access to a team of experts with many years’ experience in conducting QSARs and read-across and with high levels ofregulatory insight. Our diverse team of computational biologists, statisticians, chemists and toxicologists is flexed to match your needs.
采用最好的方法来优化预测质量和信心
采用一套QSAR建模工具来确保对所要求的任何终点的可靠预测。这可能涉及使用基于专家规则的系统和基于统计的模型来提高端点预测的置信度。
QSAR models used include:
- Biovia Discovery Studio (TOPKAT) extensible
- OECD QSAR Toolbox
- ACD / PERCEP.
- Derek Nexus.
- VEGA NIC
- 美国EPA T.E.S.T.
- US EPA EPI Suite
- ToxRead
- ToxTree