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General Toxicology
一般毒理学研究探讨了您的化学物质在单身或重复暴露后引起不良健康影响，是意外或蓄意的。效果的确切性质和严重程度取决于导致毒性，化学生物利用度，曝光途径和化学物质的曝光途径和量的机制的因素。在设计和进行一般毒理学研究时需要考虑所有这些因素。研究可能涉及急性单剂量研究或重复剂量慢性和副高压研究，观察一系列毒性终点。
- Extensive expertise in designing and conducting a full range of general toxicology全球监管，GLP和高动物福利标准的研究
- 灵活的设施和能力，以满足您的测试物种，管理途径，行政和分析路线
- 创新研究设计和技术，提高学习可靠性，提高结果和提高效率
您的需求
化学品的一般毒性测试
General toxicity endpoints are required by all chemical regulators but you need to ensure you are performing the correct studies in an efficient and strategic manner to maximize outputs. What basic studies are required? What routes of administration are needed? What is the most appropriate test species?
Our Capabilities
An expert team who can partner with you to deliver general toxicology study success in a timely manner
The dedicated toxicology team have extensive expertise in designing, planning and performing general toxicology studies. The team includes toxicologists, biologists, analytical chemists and animal technicians who working collaboratively to optimize study design and performance. From partnering with you strategically to design a full testing program to performing simple specialist studies, we can help you achieve your goals.
Our extensive facilities, flexible capacity and cutting-edge laboratories mean we can conduct studies and deliver high-quality results in a timely manner.
多种动物物种的经验和管理模式
Multiple test species are available for toxicology testing with high levels of animal welfare. As well as oral administration, Covance has expertise in dermal, subcutaneous, intravenous and intramuscular and inhalation test chemical delivery. Specialized routes of administration and delivery devices are created when necessary.
全面的一般毒理学研究
Covance已经建立了用于为您的化学品运行一般毒理学研究的屏障。这些包括标准端点以及与您的化学物质相关的独特终点。
急性毒性研究
- 经合组织测试No.402 / OCSPP 870.1200：急性皮肤毒性
- OECD Test No. 404/OCSPP 870.2500: Acute Dermal Irritation/Corrosion
- OECD Test No. 403/OCSPP 870.1300: Acute Inhalation Toxicity
- 经合组织试验号433：急性吸入 - 固定浓度程序
- 经合组织测试号405 / OCSPP 870.2400：急性眼睛刺激/腐蚀
- 经合组织420 / ocspp 870.1100：急性口腔毒性 - 固定剂量手术
- OECD Test No. 423/OCSPP 870.1100: Acute Oral Toxicity - Acute Toxic Class Method
- 经合组织测试号425 / ocspp 870.1100：急性口腔毒性：上下程序
- OECD Test No. 406/OCSPP 870.2600: Skin Sensitisation
- OECD Test No. 442A: Skin Sensitization - Local Lymph Node Assay: DA
- 经合组织试验No.442B：皮肤致敏 - 局部淋巴结测定：Brdu-Elisa
- OECD Test No. 442C: In Chemico Skin Sensitisation - Direct Peptide Reactivity Assay (DPRA)
重复剂量毒性研究
- OECD Test No. 407/OCSPP 870.3050: Repeated Dose 28-day Oral Toxicity Study in Rodents
- OECD Test No. 408/OCSPP 870.3100: Repeated Dose 90-Day Oral Toxicity Study in Rodents
- OECD Test No. 409/OCSPP 870.3150: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents
- OECD Test No. 410/OCSPP 870.3200: Repeated Dose Dermal Toxicity: 21/28-day Study
- OECD Test No. 411/OCSPP 870.3250: Subchronic Dermal Toxicity: 90-day Study
- OECD Test No. 412: Subacute Inhalation Toxicity: 28-Day Study
- OECD Test No. 413/OCSPP 870.3465: Subchronic Inhalation Toxicity: 90-day Study
神经毒性和致癌性研究
- 经合组织426号：发育神经毒性研究
- OECD Test No. 451/OCSPP 870.4200: Carcinogenicity Studies
- 经合组织452 / ocspp 870.4100：慢性毒性研究
- 经合组织453 / ocspp 870.4300：组合慢性毒性/致癌性研究