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onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/analytical-services' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">分析据span></span></a> <div> <ul class="tier-3"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>分析据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/analytical-services/bioanalytical-services' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/analytical-services/bioanalytical-services.html">Bioanalytik.据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Bioanalytik.据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/analytical-services/bioanalytical-services/lc-ms-immunoanalytical-solutions.html">但是有的Immunoanalytik据/a> <a href="//www.wfliji.com/de/services/analytical-services/bioanalytical-services/specialty-lc-ms-support.html">Spezielle LC-MS据/a> <a href="//www.wfliji.com/de/services/analytical-services/bioanalytical-services/non-glp-analytical.html">Entdeckungs-Bio.据/a> <a href="//www.wfliji.com/de/services/analytical-services/bioanalytical-services/vaccine-analysis.html">Impfstoffanalytik据/a> <a href="//www.wfliji.com/de/services/analytical-services/bioanalytical-services/validated-assays.html">方法据/a> <a href="//www.wfliji.com/de/services/analytical-services/bioanalytical-services/bioanalysis-education-center.html">Ausbildung.据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/analytical-services/drug-metabolism-and-pharmacokinetic-services' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/analytical-services/drug-metabolism-and-pharmacokinetic-services.html">DMPK.据span></span></a> <div> <ul class="tier-4 wide"> <a 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</ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/analytical-services/custom-antibody-reagents' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/analytical-services/custom-antibody-reagents.html" data-url="//www.wfliji.com/de/services/analytical-services/custom-antibody-reagents.html">Kundenspezifische Antikorper-Reagenzien据span></span></a></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/lead-optimization' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">Entdeckung和罗据span></span></a> <div> <ul class="tier-3"> <a 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href="//www.wfliji.com/de/services/lead-optimization/in-vivo-pharmacology/oncology-cell-line-assays.html">F&E Onkologische Zelllinien-Assays据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/lead-optimization/pk-tk-analysis-and-reporting' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/lead-optimization/pk-tk-analysis-and-reporting.html" data-url="//www.wfliji.com/de/services/lead-optimization/pk-tk-analysis-and-reporting.html">PK / TK据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/lead-optimization/nonclinical-imaging' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/lead-optimization/nonclinical-imaging.html">Nichtklinische Bildgebung据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Nichtklinische Bildgebung据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/lead-optimization/nonclinical-imaging/computed-tomography-ct.html">Computertomographie据/a> <a href="//www.wfliji.com/de/services/lead-optimization/nonclinical-imaging/bioluminescence-imaging.html">Biolumineszenz据/a> <a href="//www.wfliji.com/de/services/lead-optimization/nonclinical-imaging/image-analysis-services.html">分析据/a> <a href="//www.wfliji.com/de/services/lead-optimization/nonclinical-imaging/positron-emission-tomography.html">Positronen-Emission据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/lead-optimization/radiation' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/lead-optimization/radiation.html" data-url="//www.wfliji.com/de/services/lead-optimization/radiation.html">Strahlung据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/lead-optimization/flow-cytometry' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/lead-optimization/flow-cytometry.html" data-url="//www.wfliji.com/de/services/lead-optimization/flow-cytometry.html">durchflusszytometrie据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/lead-optimization/vaccines' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/lead-optimization/vaccines.html" data-url="//www.wfliji.com/de/services/lead-optimization/vaccines.html">Impfstoffe据span></span></a></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/product-testing' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">Produktprufung据span></span></a> <div> <ul class="tier-3"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Produktprufung据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/product-testing/crop' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/product-testing/crop.html">nutzpflanzen.据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>nutzpflanzen.据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/product-testing/locations.html">支持据/a> <a href="//www.wfliji.com/de/services/product-testing/crop/physical-chemistry.html">physikalische chemie据/a> <a href="//www.wfliji.com/de/services/product-testing/crop/safety-assessment.html">Menschliche Sicherheit.据/a> <a href="//www.wfliji.com/de/services/product-testing/crop/environmental-safety.html">Umweltsicherheit据/a> <a href="//www.wfliji.com/de/services/product-testing/crop/endocrine-disruptors.html">endokrine破坏（ED）据/a> <a href="//www.wfliji.com/de/services/product-testing/crop/regulatory-consultancy.html">Behordliche Beratung据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/product-testing/chemical-testing' }, collect: false, options: { obj: this }, 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href="//www.wfliji.com/de/services/product-testing/chemical-testing/environmental-safety.html">Umweltsicherheit据/a> <a href="//www.wfliji.com/de/services/product-testing/chemical-testing/endocrine-disruptors.html">endokrine破坏了据/a> <a href="//www.wfliji.com/de/services/product-testing/chemical-testing/regulatory-consultancy.html">Behordliche Beratung据/a> <a href="//www.wfliji.com/de/services/product-testing/chemical-testing/education-center.html">Bildung.据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/product-testing/locations' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/product-testing/locations.html">支持据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>支持据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/product-testing/locations/greenfield-in.html">格林菲尔德据/a> <a href="//www.wfliji.com/de/services/product-testing/locations/huntingdon-uk.html">亨廷顿据/a> <a href="//www.wfliji.com/de/services/product-testing/locations/shardlow.html">Shardlow据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/product-testing/scientific-spotlights' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/product-testing/scientific-spotlights.html">Wissenschaftliche聚光灯据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Wissenschaftliche聚光灯据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/product-testing/scientific-spotlights/oecd-229-fish-short-term-reproductive-assay.html">经合组织229年据/a> <a href="//www.wfliji.com/de/services/product-testing/scientific-spotlights/oecd-231-amphibian-metamorphosis-assay.html">经合组织231年据/a> </div></li> </ul> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/pathology' }, collect: false, options: { obj: this }, componentPath: 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href="//www.wfliji.com/de/services/safety-assessment/immunotoxicology.html" data-url="//www.wfliji.com/de/services/safety-assessment/immunotoxicology.html">Immuntoxikologie据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/safety-assessment/safety-pharmacology-services' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/safety-assessment/safety-pharmacology-services.html">Pharmakologie据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Pharmakologie据/span></li> <li class="back"><a 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href="//www.wfliji.com/de/services/safety-assessment/safety-pharmacology-services/drug-abuse-and-dependence-assessment-education-center.html">Medikamentenmissbrauchebewertungs-Bildungszentrum据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/safety-assessment/development-and-reproductive-toxicology' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology.html">飞镖据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>飞镖据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology/seg-I-fertility-and-early-embryonic-development.html">赛格我据/a> <a href="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology/seg-II-embryo-fetal-development.html">赛格二世据/a> <a href="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology/seg-III-prenatal-and-postnatal-development.html">赛格三世据/a> <a href="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology/eppnd-enhanced-pre-and-post-natal-development.html">eppnd.据/a> <a href="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology/juvenile-toxicity-studies.html">少年据/a> <a href="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology/special-evaluation-techniques.html">Spezialtechniken据/a> <a href="//www.wfliji.com/de/services/safety-assessment/development-and-reproductive-toxicology/infusion-services.html">输液据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/safety-assessment/send' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/preclinical/send.html">发送3,1.据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>发送3,1.据/span></li> <li class="back"><a 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Einreichungen.据/a> <a href="//www.wfliji.com/de/services/clinical-development/regulatory-services/writing-and-publishing.html">Medizinische Publikationen据/a> <a href="//www.wfliji.com/de/services/clinical-development/regulatory-services/regulatory-consulting-solutions-japan.html">日本据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/clinical-development/clinical-research-virtual-tours' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/clinical-development/clinical-research-virtual-tours.html" data-url="//www.wfliji.com/de/services/clinical-development/clinical-research-virtual-tours.html">Virtuellerundgängedurch die cru据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 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data-url="//www.wfliji.com/de/services/clinical-testing/bioanalytical-services.html">Bioanalytik.据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Bioanalytik.据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/clinical-testing/bioanalytical-services/validated-assays.html">Validierte化验据/a> <a href="//www.wfliji.com/de/services/clinical-testing/bioanalytical-services/bioanalysis-education-center.html">生物分析 - Bildungszentrum据/a> </div></li> </ul> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/functional-service-provider' }, collect: false, options: { obj: this }, componentPath: 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data-url="//www.wfliji.com/de/services/functional-service-provider/functional-service-provider-education-center.html">Bildung.据span></span></a></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/postmarketing' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">LösungenNachder Marktzulassung据span></span></a> <div> <ul class="tier-3"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>LösungenNachder Marktzulassung据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 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</div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/postmarketing/patient-safety-and-pharmacovigilance' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance.html">Sicherheit和光伏据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Sicherheit和光伏据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance/aggregate-reporting.html">Aggregierte Berichterstattung据/a> <a href="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance/automation.html">自动赛据/a> <a href="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance/patient-safety-consulting.html">Sicherheitsberatung据/a> <a href="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance/pharmacovigilance.html">Pharmakovigilanz (PV)据/a> <a href="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance/safety-technology.html">Sicherheitstechnologie据/a> <a href="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance/signal-detection-and-risk-management.html">Erkennung和Risikomanagement据/a> <a href="//www.wfliji.com/de/services/postmarketing/patient-safety-and-pharmacovigilance/patient-safety-resource-center.html">Ausbildung.据/a> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 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href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/device/our-strategic-approach' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/device/our-strategic-approach.html" data-url="//www.wfliji.com/de/services/device/our-strategic-approach.html">策略素ansatz.据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/device/regulatory-consulting' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/device/regulatory-consulting.html" data-url="//www.wfliji.com/de/services/device/regulatory-consulting.html">Behordliche问据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/device/preclinical-experimental-surgery' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/device/preclinical-experimental-surgery.html" data-url="//www.wfliji.com/de/services/device/preclinical-experimental-surgery.html">Praklinisch据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/device/clinical-market-approval' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/device/clinical-market-approval.html" data-url="//www.wfliji.com/de/services/device/clinical-market-approval.html">Klinisch据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/device/commercial-post-market-support' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/device/commercial-post-market-support.html" data-url="//www.wfliji.com/de/services/device/commercial-post-market-support.html">上市后据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/services/device/medical-device-education-center' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/device/medical-device-education-center.html" data-url="//www.wfliji.com/de/services/device/medical-device-education-center.html">Bildungszentrum据span></span></a></li> </ul> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="https://de.covance.com/customers.html">Kunden据span></span></a> <div> <ul class="tier-2"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Kunden据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/global-pharma' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/global-pharma.html" data-url="//www.wfliji.com/de/customers/global-pharma.html">Pharma-Unternehmen据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/biotech' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/customers/biotech.html">生物技术据span></span></a> <div> <ul class="tier-3"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>生物技术据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/biotech/partner' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/biotech/the-bio-experience.html" data-url="//www.wfliji.com/de/customers/biotech/the-bio-experience.html">合作伙伴据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/biotech/approach' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/biotech/the-bio-experience.html" data-url="//www.wfliji.com/de/customers/biotech/the-bio-experience.html">拟设据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/biotech/value' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/biotech/the-bio-experience.html" data-url="//www.wfliji.com/de/customers/biotech/the-bio-experience.html">维尔特据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/biotech/transition' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/biotech/the-bio-experience.html" data-url="//www.wfliji.com/de/customers/biotech/the-bio-experience.html">Übergang.据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/biotech/contact' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/response/LP=1647" data-url="//www.wfliji.com/response/LP=1647">kontakt.据span></span></a></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/investigators' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/customers/investigators.html">科学家klinischer Studien据span></span></a> <div> <ul class="tier-3"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>科学家klinischer Studien据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/investigators/dry-ice' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/investigators/dry-ice.html" data-url="//www.wfliji.com/de/customers/investigators/dry-ice.html">Trocockeneis.据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/investigators/order-a-kit' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/investigators/order-a-kit.html" data-url="//www.wfliji.com/de/customers/investigators/order-a-kit.html">装备代据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/investigators/become-an-investigator' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/investigators/become-an-investigator.html" data-url="//www.wfliji.com/de/customers/investigators/become-an-investigator.html">Wissenschaftler Werden.据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/investigators/accreditations-and-certifications' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/customers/investigators/accreditations-and-certifications.html" data-url="//www.wfliji.com/de/customers/investigators/accreditations-and-certifications.html">akkreditierungen und zertifizierungen.据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/investigators/investigator-study-team' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="https://de.covance.com/customers/investigators/investigator-study-team.html">Derzeitize RessourcenFürWissenschaftler据span></span></a> <div> <ul class="tier-4 wide"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Derzeitize RessourcenFürWissenschaftler据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li> <div> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/courier-contact-numbers.html">Kuriernummern.据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/ups-express.html">标签:UPS Express Critical据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/dry-ice.html">Bestellung: Trockeneis据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/institution-privacy-statement.html">Datenschutzrichtliniet:机构据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/investigator-privacy-statement.html">Datenschutzrichtlinie:科学家据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/study-staff-privacy-statement.html">Datenschutzrichtlinie: Studienteam据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/packaging-shipping-videos.html">视频:Verpackung和Versand据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/sample-collection-videos.html">视频：probennahme.据/a> <a href="//www.wfliji.com/de/customers/investigators/investigator-study-team/faqs.html">常问问题据/a> </div></li> </ul> </div></li> </ul> </div></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/participate-in-a-trial' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="https://www.covanceclinicaltrials.com/" data-url="https://www.covanceclinicaltrials.com/">Studienteilnahme.据span></span></a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/medical-device-diagnostic-solutions' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" data-url="//www.wfliji.com/de/customers/medical-device-diagnostic-solutions.html">Gerat / Diagnostik据span></span></a> <div> <ul class="tier-3"> <a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#" class="bar"></a> <li class="h2"><span>Gerat / Diagnostik据/span></li> <li class="back"><a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/#">zurück据/a></li> <li class="nav"><a onclick="CQ_Analytics.record({event:'followMegaMenu',values: { menuPath: 'https://de.covance.com/content/covance/en/customers/medical-device-diagnostic-solutions/medical-device-education-center' }, collect: false, options: { obj: this }, componentPath: 'covance-redesign/components/structure/header'})" href="//www.wfliji.com/de/services/device/medical-device-education-center.html" 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aem-GridColumn--default--12"></div> <div class="responsivegrid aem-GridColumn--tablet--12 aem-GridColumn--offset--tablet--0 aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn--tablet--none aem-GridColumn--default--9 aem-GridColumn aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0"> <div class="aem-Grid aem-Grid--9 aem-Grid--default--9 "> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <h1>Pan02: Ein mausmodel des Pankreaskarzinoms据/h1> </div> </div> </div> <div class="aem_text aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--3 aem-GridColumn--offset--default--0"> <div class="text"> <div class="text-body"> <p><b>日期:据/b>2019年6月据/p> </div> </div> </div> <div class="aem_text aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div class="text"> <div class="text-body"> <p><b>奥特:据/b>Sumithra Urs，PHD |Wissenschaftlerin，Wissenschaftliche Entwicklung据/p> </div> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <p><a href="//www.wfliji.com/solutions/oncology">kontaktieren sie据/a>Das Wissenschaftliche团队FürPräklinischeOnkologie，UM Mehr Zu Erfahren。据/p> </div> <div class="text-button"> <a class="btn btn-solid " href="//www.wfliji.com/solutions/oncology">Informationen anfordern据/a> </div> </div> </div> <div class="horizontalRule aem-GridColumn--default--9 aem-GridColumn"> <div data-emptytext="HorizontalRule Component" class="cq-placeholder"></div> <div class="covance-component"> <div class="hrule" style="margin-top: 10px;margin-bottom: 10px;"> <hr class="style-one"> </div> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <p>Bauchspeicheldrüsenkrebsist derneunthäufigstediagrosizierte krebsundzähltzudlichstenmit der niedrigsten 5-jahres-überlebensratevon 5 bis 8％。据sup>(1、2、3)据/sup>伊琳·朱尔········斯··斯科茨特死亡美国癌症协会，DASS 56.770 Menschen Mit Krankheit Diageostiziert Werden，Von Denen Mehr Als45.750MöglicherwiseNichtÜberlebenWerden。Das Duktale Adenokarzinom des Pankreas（PDAC）IST DieHäufigsteund Acgorstivste Form des Exokrinen Pankreaskarzinoms und Macht Ca.90％的艾琳·艾斯，麻省理工学院EinerMortalität，Die der Inzidenz Ontspricht。据sup>[4,5]据/sup>诊断:pdac -患者有转移性肝细胞癌，转移性肝细胞癌。我们仍然在使用克朗海特，我们也在使用克朗海特，我们也在使用克朗海特，我们也在使用克朗海特。Zu den Behandlungsoptionen für resektable患者gehören Operationen, gefolgt von einer systemchen erstlinen - chemtherapy(吉西他滨，FOLFIRINOX，紫杉醇)order einer kombinierten radiochemtherapy。Für lokal fortgeschritten, nicht resezierbare患者在接受多效化疗(5-FU，奥沙利铂，伊立替康)后接受放化疗。据sup>[6]据/sup>Da Diese Behanden uperen MitBauchspeCheDeldrüsenkrebsnur Begrenzte Vorteile Bieten，Werden Derzeit Neuere Optionen Wie Immunteputika在Klinischen Studien GeteTet。据/p> <p>PDAC sind gekenzeichnet durch das Vorhandensein eines fibrotisschen Stromas, eine geringe Mutationsbelastung, den Mangel eine CD8据sup>+据/sup>-t-zellen-infiltration und dasvorhandensein von immunsupcressiven y Myeloischen Zellpopulatenen，Die Alle Zu Denischen Nicht-Immunogene Tumoreigenschaften BeiTagen。据sup>[7]据/sup>Aktuelle Ansätze zur Verbesserung des spreens and die Behandlung konzentrieren sif if die Erhöhung des运输von T-Zellen肿瘤在Verwendung von Mitteln Strahlentherapie (RT)之下。我们的免疫系统，我们的抗肿瘤免疫系统，我们的抗肿瘤免疫系统，我们的抗肿瘤免疫系统。我们的患者在联合化疗中应该更加友好据sup>[8]据/sup>und Klinische Studien Mit Einzelwirkstoffen Zeigen Ein Schlechtes Ansprechen Mit Niedrigen Raten von 1 bis 2％。据sup>［9］据/sup>Mindestens 21 Effene Klinische Studien Untersuchen Derzeit Die Kombination von Rt Mit Anteren免疫司法德威克斯特·弗吉尼亚，Die Eine Vielversprocende选项FürIePdac-Behandlung SeinKönntenundere forschung rechtfertigen。据sup>［10］据/sup>在präklinischen平台上的Sinne evaluieren在Verwendung des murinen pan02 - pdac - models下的组合疗法中。Pan02 ist in etabliertes adenokarzinam - modelell der Stufe III, das durch chemische indukmit 3- mca (3- methylcholanthrin männlichem C57BL/6-Mäusen entwickelt wurde。据sup>[11]据/sup>在diesem模型聚光灯präsentieren线据i>in-vivo.据/i>- Zur Wachstumskinetik des Pan02-tumor-modells und Die Reaktion Auf ImmunmodulatorischeAntikörper，Fokale Strahlung und Die Kommination von Rt Mitteln，Die Im Syngenen C57BL / 6-Mausstamm GeteTet Wurden。据/p> <h3><b>Pan 02 Wachstumsparameter.据/b></h3> <p>我们在研究中(Abb. 1)(日期nicht gezeigt)植入我们的细胞。Die Wachstumskinetik ermöglicht ein therapeutics Fenster von über drei Wochen, um Die tumor- reaktionen in diem model zu bewerten。据/p> </div> </div> </div> <div class="aem_image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--7 aem-GridColumn--offset--default--0"> <div class="image"> <img class="image-img" alt="Abb. 1: Wachstumskinetik des subkutanen pan02 - models bei weiblichen C57BL/6-Mäusen。" src="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-a-murine-model-of-pancreatic-cancer/_jcr_content/root/responsivegrid_left/image.coreimg.png/1617112587548/1578077483846.png"> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <cite>Abb. 1: Wachstumskinetik des subkutanen pan02 - models bei weiblichen C57BL/6-Mäusen。据/cite> <div> <span style=""><br>Die durchflusszytometrische Immunphänotypisierungsanalyse von pan02 - tummorebestätigte Die schlechte tumor Infiltration der lymphoiden Zellen (Abb. 2)据/span> <sup>+据/sup> <span style="">和CD4.据/span> <sup>+据/sup> <span style="">辅助T细胞仅构成了1,6％和1％的CD45据/span> <sup>+据/sup> <span style="">人口分别存在免疫抑制骨髓细胞群。M-MDSC und M1-und M2-TAM Waren Dimanten Zell-Subpopulaten。Dieses tumorimmunprofil ist charakteristischfüreinnicht免疫原臭的oder“kaltes”tumormodell，ähnlichwieesbei pdac-patteren beobachtet wird。据/span> <br> </div> </div> </div> </div> <div class="aem_image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--7 aem-GridColumn--offset--default--0"> <div class="image"> <img class="image-img" alt="Abb. 1: Wachstumskinetik des subkutanen pan02 - models bei weiblichen C57BL/6-Mäusen。" src="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-a-murine-model-of-pancreatic-cancer/_jcr_content/root/responsivegrid_left/image_copy.coreimg.png/1617112587548/1578077483846.png"> </div> </div> <div class="aem_image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--7 aem-GridColumn--offset--default--0"> <div class="image"> <img class="image-img" alt="Abb 2:肿瘤免疫谱subkutaner Pan02-Tumore。" src="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-a-murine-model-of-pancreatic-cancer/_jcr_content/root/responsivegrid_left/image_copy_550180060_99572347.coreimg.png/1617112587143/1578077600964.png"> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <p><cite>Abb 2:肿瘤免疫谱subkutaner Pan02-Tumore。据br></cite></p> <h3>我想说的是据/h3> <p>Einzelwirkstoffbehandlungvonmäusenmitpan02-tumor mit gemcitabin（100 mg / kg，q3dx4），einer der amhäufigstenverwendeten chemotherapien bei atten mitbauchspeicheldstrüsenkrebs，战争vutverträglichundführtezueinerstatistisch signifikantenverzögrzögreds（ABB。3）。据/p> </div> </div> </div> <div class="aem_image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--7 aem-GridColumn--offset--default--0"> <div class="image"> <img class="image-img" alt="ABB。3：Pan02-Reaktion AUF Gemcitabin。" src="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-a-murine-model-of-pancreatic-cancer/_jcr_content/root/responsivegrid_left/image_copy_550180060.coreimg.png/1617112593211/1578077750563.png"> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <p><cite><span>ABB。3：Pan02-Reaktion AUF Gemcitabin。据br></span></cite></p> <p>Angesichts der Klinischen Untersuchung von免疫列表北PDAC战争不当Ziel，DieReaktionsfähigkeit不当Pan02-Modells Auf Eine Vielzahl von Immodulierendenantikörpernzu bewerten（abb。4）。在ÜbereinstimmungMit Dem ImmunsupcressiveInvion der Pan02-Tumore War EsNichtÜberraschend，DASS DIESES MODELL NUR MINIMAL / GAR NICHT AUF模具检查点抑制剂抗MPD-1，抗MPD-L1抗MCTLA-4 und Die KostimulatorischenAntikörper抗-mcd137 und anti-mox40 reagierte。AlleAntikörperWurdenZweimalWöchentlichMit10 mg / kgFürinsiveamt 4 opeger Gegeben（ABB。4）。据/p> </div> </div> </div> <div class="aem_image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--7 aem-GridColumn--offset--default--0"> <div class="image"> <img class="image-img" alt="Abb. 4: Pan02-Reaktion auf immunmodulerende Antikörper" src="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-a-murine-model-of-pancreatic-cancer/_jcr_content/root/responsivegrid_left/image_copy_550180060_1611872896.coreimg.png/1617112606866/1578077835490.png"> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <p><cite>ABB。4：Pan02-Reaktion AUF ImmunModulierendeAntikörper据br><br></cite></p> <h2>Strahlung和combination的翻译结果据/h2> <p>Padc-patteren werdenhäufigmit strahlentherapie behandelt。在Unsermer Mausmodell Verwendeten Wir Die小动物辐射研究平台（Sarrp; Xstrahl），UM Eine Einzelne Dosis Fokaler Strahlung（5 Gy Oder 10 Gy）Direkt An Den肿瘤Abzugeben，und Beobachteten Eine von der dosisabhängigetumorwachstumsverzögrungvon9,5 und 22Tagen Im Vergleich Zum Unbehandelten kontrollmodell（ABB。5）。据/p> </div> </div> </div> <div class="aem_image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--7 aem-GridColumn--offset--default--0"> <div class="image"> <img class="image-img" alt="Abb 5: Pan02-Reaktion auf fokale Strahlung。" src="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-a-murine-model-of-pancreatic-cancer/_jcr_content/root/responsivegrid_left/image_copy_550180060_2075718935.coreimg.png/1617112591852/1578077986457.png"> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <p><cite>Abb 5: Pan02-Reaktion auf fokale Strahlung。据br><br></cite></p> <p>UM Die Antitumorwirkungen von Rt在Kombination MIT Checkpoint-inpitoren Zu Untersuchen，Wurde Eine Einzeldiss Von 5 Gy Zusammen Mit抗MPD-1臭氧抗MPD-L1-Antikörpereingesetzt。Unbehandelte und Isotyp-kontrollguppen Zeigtenüberlappendewachstumsraten und behandlung mit Einzelwirkstoff-checkpoint-抑制剂抗MPD-1 und抗MPD-L1Löste-reaktion Aus。Währendeineeinzeldiss von 5 gy rtzueinertumorwachstumsverzögerungvon 9,5 tagengegenüberder Unbehandelten kontrollguppeführte，trug die kombination mit检查点-抑制作用Nicht Signifikant Zur Verbesserung der Antumor-Reaktion Bei。RT MIT抗MPD-1臭氧MIT抗PD-L1结果在EinerTumorWachstumsverzögrzögrzögrzögrungvonjeweils 13 und 11,2塔肯（ABB。6）。据/p> </div> </div> </div> <div class="aem_image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--7 aem-GridColumn--offset--default--0"> <div class="image"> <img class="image-img" alt="ABB。6：Pan02-Reaktion Auf Eine Kombination Aus Strahlung und Checkpoint-抑制剂。" src="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-a-murine-model-of-pancreatic-cancer/_jcr_content/root/responsivegrid_left/image_copy_550180060_979548532.coreimg.png/1617112594811/1578078075905.png"> </div> </div> <div class="aem_text aem-GridColumn--default--9 aem-GridColumn"> <div class="text"> <div class="text-body"> <p><cite>ABB。6：Pan02-Reaktion Auf Eine Kombination Aus Strahlung und Checkpoint-抑制剂。据br><br></cite></p> <h3>zukünftigearbeit mit dem pan02-modell据/h3> <p>Derzeit Laufen Studien，UM DAS Potenzial der Verwengung Mehrerer Kombinationen Zur Verbesserung des Ansprochens Auf Behandenlungen im subkutanen pan02-modell zu bewerten。Zusätzlichhabenwirskürzlicheine据a href="//www.wfliji.com/de/industry-solutions/oncology/preclinical/tumor-spotlights/pan02-luc-an-orthotopic-model-of-pancreatic-cancer.html">Luciferase-FähigePan02-Zelllinie Generiert，UM Stemien在Der Orthotopen Umgebung ZuUnterstützen据/a>。据/p> <h4>Verweise据/h4> <div> <i><br><sup>1据/sup>胰腺癌。中华医学杂志2010年4月29日;362(17):1605-17。据/i> </div> <p><sup>2据/sup>预见癌症统计事实。国家癌症研究所，国立卫生研究院。(https://www.cancer.gov)。据/p> <p><sup>3.据/sup>胰腺癌行动网络(据u>https://www.pancan.org/据/u>）.据/p> <p><sup>4.据/sup>Gunderson AJ，Yamazaki T，McCarty K等。胰腺腺癌小鼠模型中辐射处理结合成纤维细胞活化蛋白。Plos 2019,14（2）：e0211117。据/p> <p><sup>5.据/sup>Kabacaoglu D，Ciecielski KJ，Ruess Da和Algul H.免疫检查点抑制胰腺导管腺癌：当前限制和未来选择。Immunology 2018,9：1876中的前沿。据/p> <p><sup>6.据/sup>郑林。胰腺癌化疗的现行标准。中国。其他。2017年,39(11):2125 - 2134。据/p> <p><sup>7.据/sup>Azad A，Lim Sy，D'Costa Z等人。PD-L1阻断增强了胰腺导管腺癌对放射疗法的响应。EMBO，分子医学2017,9（2）：167-180。据/p> <p><sup>8.据/sup>Lauffer DC，Kuhn Pa，Kueng M等人。胰腺癌：无线化化疗后的可行性和结果，具有高剂量放射治疗，无切除和R1切除患者。2018. Cureus 10（5）：E2713。据/p> <p><sup>9.据/sup>Javle M，Golan T和Maitra A.改变胰腺癌课程 - 重点关注最近的翻译进展。癌症治疗评论。2016;44：17-25。据/p> <p><sup>10据/sup>Gajiwala S，Torgeson A，Garrido-Laguna I，Kinsey C和Lloyd S.组合免疫疗法和胰腺癌的辐射治疗策略 - 靶向癌症免疫周期中的多个步骤。J Gastro Oncol，2018;9（6）：1014-1026。据/p> <div> <i><sup>11据/sup>Corbett TH, Roberts BJ, Leopold WR, Peckham JC, Wilkoff LJ, Griswold DP Jr, Schabel FM Jr.。《中华癌症杂志》1984年第4期。据/i> </div> <div> <i></i> </div> <div> <i>请坐，请坐据a href="//www.wfliji.com/de/commitment/animal-welfare.html">Tierpflege和-nutzung据/a>gemäß den Tierschutzbestimmungen in einer aalac - akkrediten Einrichtung mit Überprüfung und Genehmigung des IACUC-Protokolls durchgeführt wurde。据/i> <br> </div> </div> </div> </div> <div class="aem_section-menu aem-GridColumn--default--9 aem-GridColumn"> <div class="section-menu"> <div class="nav_section_btn"> <a>abschnittmenü.据i class="fa fa-list" aria-hidden="true"></i></a> </div> <nav class="nav_section"> <p class="h5">Mehr Technik- und Modellspotlights据/p> <ul> 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