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免疫组织化学（IHC）
The science of immunohistochemistry (IHC) is evolving, as evidenced by the development of increasingly sophisticated automated staining platforms, production of specific antibodies for a wide range of species and the availability of a range of novel biomarkers.
IHC研究优化用于在人和动物组织中的特定靶表达/分析的染色方案可用于各种原因，例如增殖/凋亡研究，免疫肿瘤学，眼组织，肿瘤分析和组织交叉反应性。
公共IHC应用程序
- 表征免疫细胞
- 评估肿瘤细胞和免疫细胞的关系
- 可视化在标准H＆E上不可见的细胞。小胶质细胞
- Detect and measure cell proliferation
- 确定哪些患者可能从药物中获得受益
- Assess on or off target binding of an antibody drug
- Determine the specific location of a protein in a tissue sample i.e. in situ proteomics
- Track human stem cells xenotransplanted into animal models that are used to study their fate
- 研究药物代谢尤。胰岛素和胰高血糖素
- 可视化报告基因产品，如绿色荧光蛋白（GFP）
- 遵守毒理病理学会（STP）等指导
GLP IHC Features
- 具有船上抗原检索能力的自动IHC染色体：
- 徕卡债券rx.
- Ventana Discovery XT
- Ventana Discovery Ultra.
- Ventana Benchmark Ultra
- High throughput manual methods using ThermoScientific Shandon Sequenza
- 组织交叉反应性研究
- Immunophenotyping by IHC
- 多路复用，包括双IHC / ISH
- 多种最佳处理的组织库
- Experience dating back to 1988
- 以前开发的数百种方法
- 新型方法开发的科学和技术专长
What You Get at Covance
- 数百个标准和罕见（或可定制）测定
- Multiplex staining technologies (chromogenic and fluorescent)
- 大型银行最佳加工的石蜡嵌入和冷冻组织
- 主要使用一致utomated IHC platforms, validated to ensure electronic data regulatory compliance (also see SEND)
- 亚洲，欧洲和北美的全球设施之间的标准操作程序