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Translational Biomarker Solutions
探索性生物标志物的见解导致您的决策从发现到诊所
灵活，适合的生物标志物支持，以推动您的药物开发。
Accelerate your progress with a translational biomarker strategy
使用Fit-Fort-Present Assay开发和验证访问协作支持
Identify and access cutting-edge technologies and expertise
翻译生物标志物可以在帮助您快速评估生物标志物可行性方面发挥关键作用，以更好地理解如何在临床环境中使用它。谈到分析表征时，一个尺寸不适合所有。您需要一种灵活的方法，它考虑了您的开发阶段和期望的结果，以便为您的数据使用的最佳支持提供最佳支持。
Exploratory biomarkers, while not guided by specific regulations, still utilize robust quality principles, expertise and process to deliver high-quality and reliable data. A trusted partner who has familiarity with CAP/ CLIA and GxP environments can streamline your transition and retain critical insights about your assay and goals.
自2009年以来，翻译生物标志物解决方案（TBS）团队在探索性的情况下支持测定发展和验证需求 - 但原则的环境。蜂窝分析和免疫大同作用的专业知识可以帮助您从概念开发您的策略，以实现探索生物标志物的关键目标。
Specialized Support
Immunoassays/LBA
- Ultrasensitive
- Custom-immunogenicity assays
- Low-sample volume with improved detection
- Multiplexed and specialized platform assays
- Electrochemiluminescence
- Microfluidics-based ELISA
- 基于套件的免疫测定
- 免疫测定自动分析器
基于细胞的分析
- High-parameter immunophenotyping of blood, PBMC and tissues
- In vitro Pharmacology
- 细胞因子释放的免疫毒理学
- 细胞免疫学
- 基于细胞的测定（包括ADCC，CDC，增殖，细胞凋亡和活力等）
Flexible and fit-for-purpose biomarker testing solutions
From initial feasibility and development to advanced validation, testing and production, we deliver insights to drive your decision making. Our team provides unique solutions for historic (banked) samples, difficult matrix types, or complex assay development in a flexible environment that provides robust exploration to guide new paths forward in biomarker discovery. As your clinical biomarker needs evolve, the TBS team can help you transition seamlessly into a CAP/CLIA or GxP environment for qualification, method validation and implementation.
Extended reach with access to the optimal technologies
Comprehensive knowledge of assays spanning ultrasensitive and multiplexed, kit-based and custom-built, low-sample volume and cell-based, gives you an experienced partner with access to a toolbox of diverse platforms. Together, we can support your biomarker analysis and advance your discovery through the use of precision technology, such as:
- Quanterix Simoa
- 内消旋宏大e Discovery (MSD)
- luminex.
- Protein Simple ELLA
- Gyros
- Eclia（Roche E601）
- Octet
- Cytoflex (Beckman Coulter 6-color)
- Miltenyi Automacs Pro
- Miltenyi octo解离式
- BD Fortessa X-20（18色）
- CTL ImmunoSpot
A quality approach to biomarkers in a non-regulated environment
与Covance的监管实验室正常工作并行，TBS团队在一套标准化的质量原则下工作，以确保您的研究探索性目标的准确性和质量。该系统是通过内部和外部QA审计以及能力测试进一步验证，并充分确信所产生的数据符合最高标准的质量。
Working with TBS, you get a set of reliable and reconstructable results that enables informed development decisions and a structured transition to the regulatory environment required to progress to your next milestone.
接下来，符合与您合作的团队，以帮助解决您的翻译生物标志物挑战。
Erica L. Troksa, PhD
副主任，翻译生物标志物解决方案
Erica L. Troksa博士为翻译生物标志物解决方案团队提供全面的科学绩效和质量交付。她利用她16-plus years of experience indevelopment, optimization and execution of bioanalytical immunoassays. Dr. Troksa has leddevelopment and validation of novel immunoassays for multiple platforms.
Before joining Covance in March of 2013, she served as Field Scientist for EMD Millipore, training research scientists on proper techniques in multiplexing immunoassays,flow cytometry, protein quantitation and other technical applications.Dr. Troksa won the Klaus R. Unna Award as Outstanding Graduate Student at the University of Illinois at Chicago. She is the author or co-author of several peer-reviewed journal articles on various topics.
Paul C. Trampont, PhD
首席科学家和高级实验室经理，翻译生物标志物解决方案，Covance
Dr. Paul C. Trampont leads a team of scientists and technical staff responsible for developing cell-based assays to support drug development. He joined Covance in December 2014, bringing with him more than 20 years of professional experience in human immunology and oncology research. Before joining Covance, he served as Assistant Professor in the Department of Medicine, Division of Hematology and Oncology at the University of Virginia.
Dr. Trampont was awarded a Covance Scientific Excellence grant in December 2018. He is the author and co-author of numerous peer-reviewed scientific journal articles and abstracts, and is frequently invited to speak at industry conferences on topics related to method validation.
Bhaskarjyoti Sarmah, PhD
Senior Scientist and Manager, Translational Biomarker Solutions
Dr. Bhaskarjyoti Sarmah leads our team of scientists responsible for developing, validating and implementing soluble biomarker immunoassays and bioassays.他借鉴了超过10年的生物标志物工作经验，并跨多种治疗区域的目标发现研究，包括心脏代谢，肾，自身免疫/炎症疾病和免疫肿瘤。
SARMAH博士是2岁以下文章，海报和演示的作者或共同作者。在2017年1月加入Covance之前，他曾担任Eli Lilly＆Co.的生物技术发现研究的研究科学家
克里斯W. Stamatkin，PHD
Staff Scientist, Lead-Immunoassay and Special Chemistry, Translational Biomarker Solutions
Dr. Chris W. Stamatkin serves as staff scientist and lead for Immunoassay and Special Chemistry. He leads the team of scientists and technical staff responsible for developing cell-based assays to support drug development. He joined Covance in November 2017, with over 14 years of experience in laboratory research and drug development.
Dr. Stamatkin previously served as an Assistant Research Professor in the Division of Hematology/Oncology at Indiana University School of Medicine as well as Assistant Director, Therapeutic Validation Core and Angio BioCore at Indiana University Simon Cancer Center. Stamatkin shares his experience as author and co-author of numerous peer-reviewed scientific journal articles, abstracts and presentations, and is a frequent speaker at industry conferences.
Katherine (Katie) A. Masterson
免疫测定铅，平移生物标志物溶液
Ms. Masterson leads the team of scientists responsible for developing biomarker immunoassays and also consults clients on assay platforms and detection modalities. She joined Covance in January 2014, and brings over 15 years of experience in laboratory research and development to the table.
她是一个南方中心协会会员f Clinical Microbiology and is co-author of several publications and poster presentations. Before joining Covance, she served for eight years as the Virology Supervisor for the Indiana State Department of Health Laboratories.