癌症肿瘤模型

Subcutaneous (SC) tumor models发挥了重要作用在癌症药物迪斯科吗very for many years. The use of these models is a critical step along the drug discovery cascade. In vivo studies utilizing SC tumor models are incorporated into pharmacodynamic assays to ensure target inhibition and adequate inhibition of target over time.

The deep tissue location of the tumors in manyorthotopic modelsmakes the assessment of anti-cancer activity difficult without the use ofimaging techniques. Traditional methods require the sacrifice of large cohorts of animals, at different time points, to track tumor progression, metastatic spread and response to therapy.

我tastatic diseaseaccounts for the majority of cancer-related mortalities. The genes and proteins involved in metastasis have long been sought after as potential therapeutic targets. Our tumor portfolio contains a number of proprietary, efficient and reproducible metastasis models.

The use ofpatient-derived xenograft (PDX) modelshas been on the rise for the last several years. As preclinical work aims to be more relevant to clinical settings and more predictive of clinical outcomes, there are times when the use of PDX models is determined to be necessary to optimize translatability.

At Covance, we offer more than 50 different hematologic tumor lines, of both human and murine origin. We bring over a decade of industry-leading experience and expertise in model selection, study design, study execution, image acquisition and proprietary data analysis ofdisseminated tumor models.