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DNA / RNA表达分析
We use a StepOnePlus™ Real-Time PCR System that can read four different colors in a 96-well plate and supports assays such as SNP genotyping, gene expression analysis, microRNA expression, translocation analysis, and gene detection. Our PCR specialists can help you to determine the expression of specific genes in cultured cells, fresh tissues, or frozen tissues. Whether you need to measure the expression of genes in different cell lines, strains of mice, tissues, or tumors, or monitor the expression of different genes with different treatments, our PCR specialists can help you design a study that’s right for you.
Genetic instability of some cell lines can result in changes at the DNA level that can compromise research results. Cell line authentication via STR (short tandem repeat) analysis will ensure that the research is being conducted on the correct cells, maximizing reliable results, supporting publication efforts, and reducing the risk of wasted time and resources. Authenticate your cell lines by comparing the STR results to those in published sources. The STR profile of newly generated cell lines should be established so that the STR profile of future passages can be compared and the stability of the DNA can be monitored. We collaborate with a partner laboratory that specializes in STR profiling techniques and analysis.
基因表达分析是一次测量成千上万基因的活性（表达）以创建蜂窝功能的全球图像。使用下一代测序，量化并从特定基因对准，定量RNA。这些简档可以区分积极划分的细胞，显示细胞如何对特定治疗作出反应，或者确定哪些基因在不同细胞系中差异表达，小鼠，组织或肿瘤的菌株。Covance与伙伴实验室合作，专门用于测序RNA。获取测序信息后，我们有软件可以量化，对齐和分析数据。我们可以比较单一基因，相关基因组，途径组或过程特异性基因组的表达，以及样品之间的整个基因组并显示直接图和图的比较结果。