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OECD 403/OCSPP 870.1300: Acute inhalation toxicity
急性
OECD 420/OCSPP 870.1100: Acute oral toxicity (fixed dose)
The method provides information on hazardous properties and allows a substance to be classified for acute toxicity. Only moderately toxic doses are used. Research modelsare dosed in a stepwise procedure using fixed doses.
基于瞄准研究选择初始剂量水平，因为预期的剂量产生一些毒性迹象，而不会引起严重的毒性效应或死亡率。根据毒性或死亡迹象的存在或不存在，可以以更高或更低的固定剂量给药。
Results from this study can include measurements, daily detailed observations and pathology reports.
Related Capabilities
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。