.png){kind=icon}
Pre- and Postnatal Developmental Toxicity Studies
DART
OECD 414: Prenatal development toxicity study
The objectives of the prenatal development toxicity study are to detect adverse effects on the pregnant female and development of the embryo and fetus consequent to exposure of the female from implantation to the day prior to parturition.
Aims of this study design are to determine whether enhanced toxicity occurs relative to non-pregnant females, and effects on embryo-fetal survival, fetal weight and fetal development.
Studies are able to be conducted in rodents and rabbits primarily via oral gavage route of administration.
This design can also be conducted as a preliminary dose-range finding study with a smaller sample size and fewer fetal evaluations in order to determine appropriate dose levels for the definitive study.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.