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OECD 403/OCSPP 870.1300: Acute inhalation toxicity
急性
OECD 404: Acute skin irritation
经合组织404急性皮肤刺激试验提供了有关真皮应用的测试物质的健康危害，通常用于特定的农业化学或化学产品。
The OECD 439 In Vitro skin Irritation Test must be performed first to see whether it is necessary to perform the in vivo version (OECD 404). If more data are needed after the in vitro tests are completed, then the rabbit is the preferable model to produce similar hazard estimation to human skin.
Dermal irritation, signs of erythema/edema, lesion severity and levels of reversibility are evaluated. Should responses persist at the end of the observation period the test substance is considered an irritant.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。