.png){kind=icon}
代谢稳定性测定
录制类型：Evaluation
Studies measure compound half-life, calculate intrinsic clearance and predict human pharmacokinetic (PK) profiles in anticipation of first-in-human (FIH) trials.
Disappearance of a parent compound or the appearance of metabolites is measured following incubation with hepatocytes, liver microsomes or plasma, enabling calculations of half-life and intrinsic clearance.
然后可以阐明测试制品和代谢物谱的生物转化。
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。