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Human pharmacokinetics (PK) prediction
在体内临床前动物数据中使用PK的定量预测可以估算初始研究的全身暴露。yaboapp体育官网
This test can be used to predict human PK, guide first dose choices for a clinical trial, test suitability of the compound for the intended dosage regimen and predict the expected variability in human beings.
人类PK参数的预测包括间隙，分布体积，半衰期，生物利用度，有效剂量和剂量方案，血浆浓度时间曲线，间间可变性和药物 - 药物相互作用。
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。