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流式细胞术（肿瘤学）
流式细胞术（肿瘤学）
Flow cytometry in oncology drug development is commonly employed to explore changes in tumor microenvironment or systemic changes following immuno-oncology therapy. This assay can identify up to 11 different immune cell subsets (e.g., naive CD4+ and CD8+ T cells, central and effector memory T cells) in a single assay, and can also identify activation or inhibitory biomarkers on those subsets.
The most common tissues analyzed are tumor, bone marrow, draining lymph nodes, spleen as well as whole blood. In humanized mouse and CAR T/TCR, flow cytometry is widely used to assess T-cell engraftment and persistence. Ex vivo stimulation of T cells isolated from a number of tissues, including tumor, can be used to assess cytokine production (IFNg, TNFa, IL2, etc.) from specific immune cell subsets, including CD4+ and CD8+ T cells, proving a vital tool for preliminary in vitro studies to preclinical/clinical studies.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。