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Toxicity study: Fertility and early embryonic
The objective of the fertility and early embryonic toxicity study is to assess the maturation of gametes, mating behavior, fertility, preimplantation development of the embryo and implantation.
For females, this assessment includes effects on estrous cycles, tubal transport, implantation and embryonic development. For males, this study design will detect functional effects (i.e., libido, sperm maturation). Sperm assessments (concentration, motility and morphology) can be conducted as needed.Fresh semen collection can be used for longitudinal assessment of test article exposure.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.