Cerebrospinal fluid (CSF) concentrations can be used as a surrogate measure of the central nervous system's (CNS) availability of drugs.

Systemically administered drugs can reach CSF either directly via passage across the choroid plexus or indirectly by passage across the blood-brain barrier (BBB), followed by diffusion/convection transport from the interstitial fluid（ISF）到CSF。

研究模型研究中的CSF渗透用于评估早期临床前药物发育中的CNS药物递送。yaboapp体育官网为了在CNS中进行化合物的完整药代动力学（PK）分布，需要多个CSF采样时间点。

提供插管和直接棒（啮齿动物，犬，NHP）型号，因为串行生存采样和殖民地利用的能力。